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KMID : 0358419960390050913
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Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 5 p.913 ~ p.918
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Effects on Serum Lipid and Lipoproteins of Continuously Adding Medroxyprogesterone Acetate to Conjugated Equine Estrogen Therapy in Postmenopausal Women
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김정욱
김병석/장전호/전현아/이경희/박만철/이용우/윤종률
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Abstract
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This study evaluates the impact on serum lipid and lipoproteins of adding continuously medroxyprogesterone acetate to conjugated equine estrogens in postmenopausal women. That is whether concomitant progesterone administration opposes beneficial
effect
of estrogen on lipoproteins whiles reducing the incidence of endometrial hyperplasia and cancer, or not.
We studied on 31 menopausal women who had never hormonal therapy and no history of stroke, diabetes or any other cardiac, hepatic or renal disorder. Group A patients(n=16) were castrated postmenopausal women for at least 1 year and were given
daily
conjugated equine estrogen 0.65 mg for 6 months, Group B patients(n=15) received daily conjugated equine estrogen 0.625mg and medroxprogesterone acetate 2.5mg for at least 6 months.
Pre- and post-treatment evaluation of serum lipoprotein concentration demonstrated significant declines in total cholesterol(10.35% and 12.34%) and low-density lipoprotein cholesterol(24.21% and 28.13%) and significant increases high-density
lipoprotein(16.18% and 11.69%) and triglyceride(23.59% and 25.40%) within group A and group B(P<0.05).
And on differences were noted in the degree of changes of post-treatment serum levels in total cholesterol, high-density lipoprotein cholesterol, triglyceride between two groups.
In conclusion, medroxyprogesterone acetate at low doses in continuously combined administration in estrogen replacement therapy does not oppose the beneficial estrogen-induced lipoprotein changes.
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KEYWORD
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